The final 20S proteasome product looks less like cartoon mechanized lions forming a microscopic Voltron and more like a humble barrel, albeit just as destructive to proteins targeted for recycling ...

Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell’s recycling process for obsolete and misshapen proteins—known as proteasomes ...

Today’s Android phones are significantly more advanced than they were just a few years ago, but one thing hasn’t changed: the need for a SIM card. Every phone needs a physical or eSIM card to ...

I hadn’t bought a new SIM card; it was as simple as activating a different eSIM using an app in my phone. Within seconds, I was retrieving emails, downloading WhatsApp messages and checking the ...

The Google Pixel 8 has eSIM support and a single physical nano-SIM card slot. Using both the eSIM and the nano-SIM card slot allows you to take advantage of dual-SIM functionality. Is the Google ...

1. Choose your new deal Select a deal below and click through to the network’s site. 2. Get your PAC code You’ll need a special code to keep your number when you switch. It's quick and free ...

Whether you choose a pay-as-you-go (PAYG) or a Sim-free deal, or you want a cheap contract to buy a handset now, we've rounded up some of the best deals on the latest handsets. Read our guide to the ...

More information: Jin Ju Lim et al, Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner, Autophagy (2024). DOI: 10.1080 ...