In most murine species, spermatozoa exhibit a falciform apical hook at the head end. The function of the sperm hook is not yet clearly understood. In this study, we investigate the role of the sperm ...

Researchers have developed the first 3D map of gene regulation in the human brain, offering insights into how early brain ...

Scientists at St. Jude Children's Research Hospital have revealed how Fanzor2's divergence from bacterial ancestors may make ...

Elizabeth Kellogg, PhD, St. Jude Department of Structural Biology, studied the structure of Fanzor2 to chart how these systems have evolved, offering key insights to inform future approaches to ...

DNA—the molecule that carries the genetic information of all living organisms—is packaged within cells in a complex manner ...

Elizabeth Kellogg, PhD, St. Jude Department of Structural Biology, used cryo-EM to study the evolutionary journey of Fanzor2, a compact eukaryotic genome-editing protein with huge potential.

Calcineurin fine tunes the balance between proliferation and differentiation of Notch-responsive progenitors in the pancreatic ducts to enable beta cell regeneration in zebrafish.

These results pave the way for more effective gene therapies for neuromuscular ... based on protein structure prediction, to predict the efficiency and stability of the new capsid.

Vironexis Biotherapeutics has unveiled with $26 million and a clinical-trial-ready gene therapy that has already nabbed FDA fast track and rare pediatric disease tags. The San Diego-based biotech ...