CPTX—A Synaptic “Glue” Restores Memory in Alzheimer’s Model
WEBSep 4, 2020 — Super-resolution microscopy showed the chimera working as a go-between among presynaptic VgluT2 and postsynaptic GluA4, which are expressed by most excitatory motor neurons in the spinal cord. The synaptic organizer improved locomotion as judged by the Basso mouse scale, when given one week after the injury ( Basso et al., 2006 ).
Do Tau Fibrils Form Via Droplets? - ALZFORUM
WEB19 Jul 2024. How do tau fibrils develop? In the July 19 Structure online, scientists led by Yoshiyuki Soeda and Akihiko Takashima at Gakushuin University, Tokyo, proposed that the protein first condenses into droplets, then folds into insoluble β sheets. When the authors forced mutant human tau in a mouse cell line to come together, it ...
Put a RING on It: Targeting Intracellular Tau Aggregates for ...
WEBSep 20, 2024 — That would be more likely for the RING-sdAb, considering that we recently reported that three intravenous injections of a rather low dose of an anti-α-synuclein sdAb, or its proteolysis targeting chimera derivative (3 mg/kg), cleared α-synuclein from the brain of synucleinopathy mice, with the PROTAC derivative being more effective (Jiang et ...
All About Exposure: How to Get Enough Progranulin into the Brain?
WEBJun 21, 2024 — It targets the mouse liver, from where it pumped a continuous supply of the fusion protein into the blood stream after a single injection. In the blood the chimera floated into the cerebrovasculature, where it crossed the blood-brain barrier. Importantly, it reached every nook and cranny of the brain parenchyma.
Tau Receptor Identified on Cell Surface - ALZFORUM
WEBMar 7, 2020 — At Tau2020, a new conference held February 12 and13 in Washington, D.C., Ken Kosik, University of California, Santa Barbara, reported that tau slips into cultured human neurons by binding LDL-receptor-related protein 1 (LRP1), a cell surface receptor. In mice, knocking down LRP1 expression shut down the spread of injected mutant tau.
Are Protein Strains The Cause of Different Tauopathies?
WEBSeeding induced aggregation of the yellow chimera. As the cells grew and multiplied over the next 20 days, Sanders saw a gradual loss of aggregates. However, a small percentage of cells retained obvious yellow inclusions even up to six months and many cell generations later, when the initial tau seed was long gone from the culture medium.
Methylated RNA: A New Player in Tau Toxicity? - ALZFORUM
WEBSep 14, 2021 — Being the most abundant mRNA modification, this methylation controls mRNA metabolism. This caught Jiang’s eye. M 6 A RNA is upregulated in the APP/PS1 mouse brain, and the enzyme that adds the m 6 A modification accumulates with insoluble tau in postmortem AD brain tissue (Han et al., 2020; Huang et al., 2020).
Reprogramming Fibroblasts—A New Route to Stem Cells?
WEBAug 31, 2005 — A green fluorescent protein chimera of the Rex1 embryonic gene that was inserted into the fibroblast genome was turned on once the cells fused. But more importantly, transcriptional profiling showed that of over 6,000 genes in the fibroblast genome that are either quiescent (2,541 genes) or …
Neuron-Protecting P7C3 Compounds Take Steps Toward the Clinic
WEBSep 26, 2014 — The compounds benefit mouse models of amyotrophic lateral sclerosis, Parkinson’s disease, and traumatic brain injury (see Oct 2012 news story; Yin et al., 2014). Despite this evidence of P7C3’s positive effects, the …
APPSwe (line C3-3) - ALZFORUM
WEBSummary. These transgenic mice express a chimeric mouse/human APP carrying the Swedish mutation under the control of the mouse prion protein promoter. This line, C3-3, was generated in parallel with line E1-2, which also expresses APP carrying the Swedish mutation. Mice that are hemizygous for the transgene are viable and fertile and express ...